A 2017 systematic review found evidence supporting effectiveness of osteopathic treatment in decreasing pain intensity and frequency, as well as reducing future pain episodes in adults with headache. The study was reviewing the efficacy, effectiveness, safety, and tolerability of osteopathy in patients with primary headaches
Cerritelli F, Lacorte E, Ruffini N, Vanacore N. Osteopathy for primary headache patients: a systematic review. J Pain Res. 2017;10:601–611. Published 2017 Mar 14. doi:10.2147/JPR.S130501 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5359118/